RANIBIZUMAB
RANIBIZUMAB Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody Fab fragment, directed against human vascular endothelial growth factor A (VEFG-A). [1] Brand name:- Lucentis, Byooviz, Cimerli, Susvimo [1], Razumab Generic name:- Ranibizumab [1] Protein chemical formula:- C 2158 H 3282 N 562 O 681 S 12 [1] Protein size:- 48349.6111 Da [1] Seuences:- >Ranibizumab Light Chain DIQLTQSPSSLSASVGDRVTITCSASQDISNYLNWYQQKPGKAPKVLIYFTSSLHSGVPS RFSGSGSGTDFTLTISSLQPEDFATYYCQQYSTVPWTFGQGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC >Ranibizumab Heavy Chain EVQLVESGGGLVQPGGSLRLSCAASGYDFTHYGMNWVRQAPGKGLEWVGWINTYTGEPTY AADFKRRFTFSLDTSKSTAYLQMNSLRAEDTAVYYCAKYPYYYGTSHWYFDVWGQGTLVT VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVL QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHL [1] Defination:- Humanized Antibody Humanised antibodies (suffix -zumab) are produced by gra